Granzyme A-producing type 1 innate lymphoid cells promote salivary secretion in the aged submandibular gland
Aged submandibular salivary glands accumulated ILC1s that promote epithelial function through a GZMA-dependent pathway and increased AQP5 expression, thereby maintaining salivary secretion during early aging. These findings identify ILC1s as regulators of salivary gland homeostasis and highlight the GZMA-Pard3 axis as a potential therapeutic target.
Authors
- Daisuke Okuzaki (ORCID: https://orcid.org/0000-0002-4552-783X)
- Erika Yamashita
- Masaru Ishii (ORCID: https://orcid.org/0000-0002-4215-007X)
- Hiroaki Abe
Institutions
- Ube Frontier University (JP)
- National Institute of Biomedical Innovation, Health and Nutrition (JP)
- Osaka International University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Inflammation and Regeneration
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1186/s41232-026-00407-7
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00