First characterization of insertions in the HIV-1 integrase-coding region from people with HIV

Our study has revealed that the mutations observed in people living with HIV-1 do not confer resistance to anti-integrase compounds but are detrimental to viral replication.

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Publication Details

Journal
Journal of Antimicrobial Chemotherapy
Published
2025-12-19
DOI
https://doi.org/10.1093/jac/dkaf491
Primary Topic
HIV/AIDS drug development and treatment
Type
article
Field-Weighted Citation Impact
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article

First characterization of insertions in the HIV-1 integrase-coding region from people with HIV

Clémence Richetta, Audrey Mirand, Patrice Gouet, Magali Bouvier‐Alias et al.
Journal of Antimicrobial Chemotherapy
HIV/AIDS drug development and treatment
article

First characterization of insertions in the HIV-1 integrase-coding region from people with HIV

Clémence Richetta, Audrey Mirand, Patrice Gouet, Magali Bouvier‐Alias, Olivier Delelis, Gladys Mbemba, Vincent Parissi, Camille Tumiotto, Delphine Lapaillerie, Eric Deprez, Soizic Le Mestre, Thomas Montrouge, Nhat Quang Tu, Charlotte Charpentier, Melissa Stampetta, Véronique Avettand-Fenoël, Marc Wirden, Coralie Pallier, Diane Descamps
article en

Abstract

Our study has revealed that the mutations observed in people living with HIV-1 do not confer resistance to anti-integrase compounds but are detrimental to viral replication.

Journal of Antimicrobial ChemotherapyVol. 81(2)
Université Claude Bernard Lyon 1 (FR), Délégation Paris 5 (FR), Centre National de la Recherche Scientifique (FR), Université de Bordeaux (FR), Inserm (FR), Lyon College (US), Université Paris Cité (FR), Université Paris-Saclay (FR), Centre Hospitalier Universitaire Henri-Mondor (FR), Sorbonne Université (FR), Sorbonne Paris Cité (FR), Structural and Molecular Basis of Infectious Systems (FR), Assistance Publique – Hôpitaux de Paris (FR), Hospices Civils de Lyon (FR), Centre de Recherche en Cancérologie de Lyon (FR), Centre Hospitalier Universitaire de Clermont-Ferrand (FR), Hôpitaux Universitaires Henri-Mondor (FR), Institut Pierre Louis d‘Épidémiologie et de Santé Publique (FR), Institut Cochin (FR), Hôpital Bichat-Claude-Bernard (FR), Laboratoire de Biologie et Pharmacologie Appliquée (FR), Institut Polytechnique de Bordeaux (FR), Hôpital Paul-Brousse (FR)
Good health and well-being
Openalex Percentile: Top 28%
HIV/AIDS drug development and treatment
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