LncRNA HULC/miR-556-5p Axis Attenuates Ang II-Induced CardiacMicrovascular Endothelial Cell Dysfunction by Suppressing theAMPK/FOXO3 Pathway

This study elucidates the important role of the LncRNA HULC/miR-556- 5p axis in endothelial cell injury associated with heart failure. Our findings provide new insights into the pathophysiological mechanisms of heart failure and highlight the potential therapeutic value of targeting this axis to improve endothelial cell function.

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Publication Details

Journal
Current Molecular Medicine
Published
2026-01-26
DOI
https://doi.org/10.2174/0115665240395360251112160900
Primary Topic
Cancer-related molecular mechanisms research
Type
article
Field-Weighted Citation Impact
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article

LncRNA HULC/miR-556-5p Axis Attenuates Ang II-Induced CardiacMicrovascular Endothelial Cell Dysfunction by Suppressing theAMPK/FOXO3 Pathway

Yafeng Hao, Mingming Fu, Zhiqian Wang
Current Molecular Medicine
Cancer-related molecular mechanisms research
article

LncRNA HULC/miR-556-5p Axis Attenuates Ang II-Induced CardiacMicrovascular Endothelial Cell Dysfunction by Suppressing theAMPK/FOXO3 Pathway

Yafeng Hao, Mingming Fu, Zhiqian Wang
article en

Abstract

This study elucidates the important role of the LncRNA HULC/miR-556- 5p axis in endothelial cell injury associated with heart failure. Our findings provide new insights into the pathophysiological mechanisms of heart failure and highlight the potential therapeutic value of targeting this axis to improve endothelial cell function.

Current Molecular MedicineVol. 26
Hebei Medical University (CN), Third Hospital of Hebei Medical University (CN)
Good health and well-being
Openalex Percentile: Top 75%
Cancer-related molecular mechanisms research
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LncRNA HULC/miR-556-5p Axis Attenuates Ang II-Induced CardiacMicrovascular Endothelial Cell Dysfunction by Suppressing theAMPK/FOXO3 Pathway — Yafeng Hao, Mingming Fu, et al. · Current Molecular Medicine (2026) | TGRS Research Map | TGRS