Ameliorative effects of vitamin C and garlic (Allium sativum) on nifedipine-induced reproductive dysfunction in a male albino rat model

Nifedipine caused significant impairments in sperm quality and histological integrity. Vitamin C and garlic combination produced a statistically significant improvement in normal sperm morphology, with other parameters showing non-significant numerical increases. Further research with larger sample sizes and biochemical analyses is needed to clarify the extent of antioxidant influence on nifedipine-induced reproductive alterations.

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Publication Details

Journal
Frontiers in Veterinary Science
Published
2026-01-29
DOI
https://doi.org/10.3389/fvets.2025.1725725
Primary Topic
Garlic and Onion Studies
Type
article
Field-Weighted Citation Impact
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article

Ameliorative effects of vitamin C and garlic (Allium sativum) on nifedipine-induced reproductive dysfunction in a male albino rat model

Ugochinyere Juliet Njoga, Samuel Okezie Ekere, Mark Ebubechukwu Awachie, Izuchukwu S. Ochiogu et al.
Frontiers in Veterinary Science
Garlic and Onion Studies
article

Ameliorative effects of vitamin C and garlic (Allium sativum) on nifedipine-induced reproductive dysfunction in a male albino rat model

Ugochinyere Juliet Njoga, Samuel Okezie Ekere, Mark Ebubechukwu Awachie, Izuchukwu S. Ochiogu, K. O. Anya, Lawrence U. Eze, Faith. N. Amune, Loveth C. Ojimba, Emmanuel O. Njoga
article en

Abstract

Nifedipine caused significant impairments in sperm quality and histological integrity. Vitamin C and garlic combination produced a statistically significant improvement in normal sperm morphology, with other parameters showing non-significant numerical increases. Further research with larger sample sizes and biochemical analyses is needed to clarify the extent of antioxidant influence on nifedipine-induced reproductive alterations.

Frontiers in Veterinary ScienceVol. 12
University of Nigeria (NG), General Department of Preventive Medicine (VN), Department of Animal Health (VN), University of Veterinary Medicine (HU)
Openalex Percentile: Top 75%
Garlic and Onion Studies
DOIOpen Access PDFOpenAlex
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Ameliorative effects of vitamin C and garlic (Allium sativum) on nifedipine-induced reproductive dysfunction in a male albino rat model — Ugochinyere Juliet Njoga, Samuel Okezie Ekere, et al. · Frontiers in Veterinary Science (2026) | TGRS Research Map | TGRS