Modeling GABAergic hyperexcitability in sleep bruxism patient-derived brainstem neurons using a multielectrode array platform
We developed a robust, high-throughput MEA platform that reliably quantifies SB-related electrophysiological phenotypes. Our findings indicate that SB-derived GABAergic neurons exhibit constitutive hyperexcitability and excessive GABA release, providing mechanistic insights and a scalable framework for therapeutic discovery.
Authors
- Yuka Abe (ORCID: https://orcid.org/0000-0001-7124-879X)
- Kazuyoshi Baba (ORCID: https://orcid.org/0000-0001-8025-2168)
- Taro Sato
- Akihiro Yamaguchi
- Wado Akamatsu
- Mayu Onishi
- Miho Fujishima
Institutions
- SHOWA Medical University (JP)
- Juntendo University (JP)
Publication Details
- Journal
- Journal of Oral Biosciences
- Published
- 2026-01-29
- DOI
- https://doi.org/10.1016/j.job.2026.100743
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00