The importance of staying within range: associations between tacrolimus intrapatient variability and kidney transplant outcomes
Multiple markers of tacrolimus underexposure were independently associated with poor post-transplant outcomes. These findings underscore the critical importance of maintaining tacrolimus levels within the target therapeutic range during the early post-transplant period to optimize long-term kidney transplant outcomes.
Authors
- Claudius Speer (ORCID: https://orcid.org/0000-0002-3668-5916)
- Bernd Döhler (ORCID: https://orcid.org/0000-0003-0051-096X)
- Christian Morath (ORCID: https://orcid.org/0000-0003-2218-7817)
- Thuong Hien Tran (ORCID: https://orcid.org/0000-0001-8587-5989)
- L Wittig
- Louise Benning (ORCID: https://orcid.org/0000-0002-8366-2100)
- Martin Zeier
- Maarten Busse
Institutions
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- Nuremberg Hospital (DE)
- Paracelsus Medizinische Privatuniversität (DE)
- Institute of Immunology (HR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.3389/fimmu.2026.1739104
- Primary Topic
- Renal Transplantation Outcomes and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Dietmar Hopp Stiftung
- Universitätsklinikum Heidelberg