Canonical and noncanonical NF-kappa B signaling in uveal melanoma: mechanisms, microenvironment, and therapeutic modulation

NF-κB signaling, particularly the canonical branch, is required for UM malignancy, while noncanonical signaling is linked with high-risk features. Branch-specific genetic manipulations and clinically relevant models should be employed in future research to maximize therapeutic strategies.

Authors

Imán Dianat (ORCID: https://orcid.org/0000-0001-6282-939X)
Reza Izadfar
Gholamhosein Lohrasbi
Faezeh Firuzpour
Hamid Reza Esfandiari
Sobhan Jalali
Sina Baghi Keshtan

Institutions

Islamic Azad University Kazeron (IR)
Tehran University of Medical Sciences (IR)
Babol University of Medical Sciences (IR)
Birjand University of Medical Sciences (IR)

Publication Details

Journal: Medical Hypothesis Discovery & Innovation in Ophthalmology
Published: 2025-12-17
DOI: https://doi.org/10.51329/mehdiophthal1534
Primary Topic: Ocular Oncology and Treatments
Type: article
Field-Weighted Citation Impact: 0.00

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article

Canonical and noncanonical NF-kappa B signaling in uveal melanoma: mechanisms, microenvironment, and therapeutic modulation

Imán Dianat, Reza Izadfar, Gholamhosein Lohrasbi, Faezeh Firuzpour et al.

Dec 17, 2025

Medical Hypothesis Discovery & Innovation in Ophthalmology

Ocular Oncology and Treatments

article

Canonical and noncanonical NF-kappa B signaling in uveal melanoma: mechanisms, microenvironment, and therapeutic modulation

Imán Dianat, Reza Izadfar, Gholamhosein Lohrasbi, Faezeh Firuzpour, Hamid Reza Esfandiari, Sobhan Jalali, Sina Baghi Keshtan

December 17, 2025article en

Abstract

NF-κB signaling, particularly the canonical branch, is required for UM malignancy, while noncanonical signaling is linked with high-risk features. Branch-specific genetic manipulations and clinically relevant models should be employed in future research to maximize therapeutic strategies.

Medical Hypothesis Discovery & Innovation in OphthalmologyVol. 14(4)

Islamic Azad University Kazeron (IR), Tehran University of Medical Sciences (IR), Babol University of Medical Sciences (IR), Birjand University of Medical Sciences (IR)

Good health and well-being

Openalex Percentile: Top 26%

Ocular Oncology and Treatments

DOI Open Access PDF OpenAlex

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Canonical and noncanonical NF-kappa B signaling in uveal melanoma: mechanisms, microenvironment, and therapeutic modulation — Imán Dianat, Reza Izadfar, et al. · Medical Hypothesis Discovery & Innovation in Ophthalmology (2025) | TGRS Research Map | TGRS