Identification of small molecule inhibitors targeting FGFR through molecular docking-based screening
We predicted three small molecules targeting FGFRs, and ZINC000101867325 shows superior chemical bond types and stability with FGFR1/2/3, and inhibits FGFR signaling in CRC cell lines. This study provides novel FGFRs inhibitors, which enrich treatment strategies for cancers.
Authors
- Ke Zheng (ORCID: https://orcid.org/0000-0001-7365-1232)
- Kong Qingran
- Weibo Hou
- Qi Zhao
- Xinyu Wang
- Kun Liu
- Ping Wang
- Liang Cheng
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Sichuan University (CN)
- National Health and Family Planning Commission (CN)
- West China Second University Hospital of Sichuan University (CN)
- Heilongjiang Academy of Sciences (CN)
- Ningbo Medical Center Lihuili Hospital (CN)
- Shanghai East Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-29
- DOI
- https://doi.org/10.3389/fonc.2026.1733391
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00