Activator protein-1 (AP-1) inhibition prevents endothelial to mesenchymal transition in diabetes-associated atherosclerosis: a translational study

This study identifies AP-1 inhibition with T-5224 as a potential therapeutic approach for EndMT resulting in reduced atherosclerosis in diabetes. The use of human serum underscores the translational relevance of these findings.

Authors

Institutions

Publication Details

Journal
Cardiovascular Diabetology
Published
2026-01-29
DOI
https://doi.org/10.1186/s12933-025-03060-5
Primary Topic
Congenital heart defects research
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Activator protein-1 (AP-1) inhibition prevents endothelial to mesenchymal transition in diabetes-associated atherosclerosis: a translational study

Scott Maxwell, Francesco Paneni, Jun Okabe, Aozhi Dai et al.
Cardiovascular Diabetology
Congenital heart defects research
article

Activator protein-1 (AP-1) inhibition prevents endothelial to mesenchymal transition in diabetes-associated atherosclerosis: a translational study

Scott Maxwell, Francesco Paneni, Jun Okabe, Aozhi Dai, Misbah Aziz, Karin AM Jandeleit-Dahm, Emma Pyper, Karly C Sourris, Jairo P Cortes, Abdul Waheed Khan, Tomasz J Block, Mark E Cooper
article en

Abstract

This study identifies AP-1 inhibition with T-5224 as a potential therapeutic approach for EndMT resulting in reduced atherosclerosis in diabetes. The use of human serum underscores the translational relevance of these findings.

Cardiovascular DiabetologyVol. 25(1)
Baker Heart and Diabetes Institute (AU), Monash Alfred Psychiatry Research centre (AU), University Hospital of Zurich (CH), Deutsches Diabetes-Zentrum e.V. (DE), Heinrich Heine University Düsseldorf (DE), Monash University (AU)
Good health and well-being
Openalex Percentile: Top 76%
Congenital heart defects research
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Activator protein-1 (AP-1) inhibition prevents endothelial to mesenchymal transition in diabetes-associated atherosclerosis: a translational study — Scott Maxwell, Francesco Paneni, et al. · Cardiovascular Diabetology (2026) | TGRS Research Map | TGRS