Non-Uremic Calciphylaxis Without End-Stage Renal Disease: A Case Report

Calciphylaxis is a rare but life-threatening disorder of medial arteriolar calcification with subsequent thrombosis, most often associated with end-stage renal disease (ESRD). Non-uremic calciphylaxis (NUC) – which occurs in the absence of ESRD— is even rarer, with limited literature describing its clinical course, management, and outcomes. We present the case of a 62-year-old female with rheumatoid arthritis and no history of ESRD who developed progressive bilateral lower extremity ulcerations complicated by recurrent infections. Her clinical course was characterized by treatment resistance, multiple hospitalizations, and poor wound healing, requiring a multidisciplinary approach including intravenous sodium thiosulfate, wound care, and hyperbaric oxygen therapy. This case highlights the diagnostic challenges of NUC, its high morbidity, the importance of early recognition, and combined therapeutic strategies.