Juvenile toxicity and developmental safety of Zintrodiazine, a novel antimalarial candidate, in Wistar rats
Zintrodiazine demonstrated a favourable juvenile safety profile, with no adverse effects on growth, neurodevelopment or sexual maturation at clinically relevant exposures. These findings provide critical regulatory data supporting progression into paediatric clinical trials and highlight Zintrodiazine's potential as a safe and effective antimalarial for children.
Authors
- A. Nyska
- Jitendra H. Patel (ORCID: https://orcid.org/0009-0005-3703-5703)
- Belén Tornesi
- Ramchandra Ranvir
- Laxit K. Bhatt (ORCID: https://orcid.org/0000-0002-1227-7408)
- Viral I. Rajwadi
- Rajesh Sundar
- Beata Kusmider
- Hitesh Kadu
- Mukul R. Jai
- Pratik P Panchal
- Ravi R Trivedi
- Vipul B Chauhan
- Jigar V Shah
- Harilal Patel
Institutions
- Tel Aviv University (IL)
- Zydus Lifesciences Limited (India) (IN)
- Medicines for Malaria Venture (CH)
Publication Details
- Journal
- Journal of Antimicrobial Chemotherapy
- Published
- 2026-01-08
- DOI
- https://doi.org/10.1093/jac/dkag008
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 0.00