Surgery vs. non-surgery for advanced cholangiocarcinoma post-conversion therapy with PD-1/PD-L1 inhibitors plus TKIs

For patients with initially unresectable CCA, PD-1/PD-L1 inhibitors plus TKIs can successfully downstage the tumor. Conversion surgery is safe and feasible, and surgical treatment can improve patients' OS and PFS.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-01-29
DOI
https://doi.org/10.3389/fimmu.2026.1753437
Primary Topic
Cholangiocarcinoma and Gallbladder Cancer Studies
Type
article
Field-Weighted Citation Impact
0.00

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article

Surgery vs. non-surgery for advanced cholangiocarcinoma post-conversion therapy with PD-1/PD-L1 inhibitors plus TKIs

Zhiguo Tan, Lishun Yang, Chuang Peng, Zengpeng Sun et al.
Frontiers in Immunology
Cholangiocarcinoma and Gallbladder Cancer Studies
article

Surgery vs. non-surgery for advanced cholangiocarcinoma post-conversion therapy with PD-1/PD-L1 inhibitors plus TKIs

Zhiguo Tan, Lishun Yang, Chuang Peng, Zengpeng Sun, Jia Zhou, Ou Li, Xu Chen, Yutao Wang
article en

Abstract

For patients with initially unresectable CCA, PD-1/PD-L1 inhibitors plus TKIs can successfully downstage the tumor. Conversion surgery is safe and feasible, and surgical treatment can improve patients' OS and PFS.

Frontiers in ImmunologyVol. 17
Hunan Normal University (CN)
Natural Science Foundation of Hunan Province
Good health and well-being
Openalex Percentile: Top 76%
Cholangiocarcinoma and Gallbladder Cancer Studies
DOIOpen Access PDFOpenAlex
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