An Immune Cell Activation Signature for Non - Small Cell Lung Cancer Revealed Tumor Microenvironment Heterogeneity and the Role of RORA in Regulating ZNF490/NDUFA12 Axis

The model is robust and effectively reflects NSCLC heterogeneity while predicting prognosis. RORA promotes the expression of ZNF490 to inhibit NUDFs and oxidative phosphorylation.

Authors

Zhen Zhu (ORCID: https://orcid.org/0000-0003-0530-1526)
Shuang Song (ORCID: https://orcid.org/0000-0002-9521-8867)
Yiyi Song
Xin Lin
Hong Li

Institutions

Shanghai Sixth People's Hospital (CN)

Publication Details

Journal: Current Medicinal Chemistry
Published: 2026-01-26
DOI: https://doi.org/10.2174/0109298673399740251007015341
Primary Topic: Ferroptosis and cancer prognosis
Type: article
Field-Weighted Citation Impact: 0.00

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article

An Immune Cell Activation Signature for Non - Small Cell Lung Cancer Revealed Tumor Microenvironment Heterogeneity and the Role of RORA in Regulating ZNF490/NDUFA12 Axis

Zhen Zhu, Shuang Song, Yiyi Song, Xin Lin et al.

Jan 26, 2026

Current Medicinal Chemistry

Ferroptosis and cancer prognosis

article

An Immune Cell Activation Signature for Non - Small Cell Lung Cancer Revealed Tumor Microenvironment Heterogeneity and the Role of RORA in Regulating ZNF490/NDUFA12 Axis

Zhen Zhu, Shuang Song, Yiyi Song, Xin Lin, Hong Li

January 26, 2026article en

Abstract

The model is robust and effectively reflects NSCLC heterogeneity while predicting prognosis. RORA promotes the expression of ZNF490 to inhibit NUDFs and oxidative phosphorylation.

Current Medicinal ChemistryVol. 33

Shanghai Sixth People's Hospital (CN)

Good health and well-being

Openalex Percentile: Top 77%

Ferroptosis and cancer prognosis

DOI Source OpenAlex

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An Immune Cell Activation Signature for Non - Small Cell Lung Cancer Revealed Tumor Microenvironment Heterogeneity and the Role of RORA in Regulating ZNF490/NDUFA12 Axis — Zhen Zhu, Shuang Song, et al. · Current Medicinal Chemistry (2026) | TGRS Research Map | TGRS