Miliary Tuberculosis With Immune Thrombocytopenia in 50‐Year‐Old Ethiopian Woman: A Case Report and Brief Review of Literature

Immune thrombocytopenia (ITP) is a rare but recognized hematologic complication of tuberculosis (TB), particularly miliary TB. We present a case of a 50-year-old female with severe thrombocytopenia and hemorrhagic manifestations secondary to miliary TB. The patient presented with mucocutaneous bleeding, anemia, and constitutional symptoms. Investigations revealed severe thrombocytopenia (11,000/μL), erythroid hyperplasia on bone marrow aspiration, and radiographic findings consistent with miliary TB, later confirmed by sputum GeneXpert. Management included short-course high-dose dexamethasone for acute bleeding, followed by anti-tuberculosis therapy (ATT), which led to sustained platelet recovery without further immunosuppression. This case highlights miliary TB as a reversible cause of secondary ITP and underscores the importance of investigating underlying infections in patients presenting with thrombocytopenia in TB-endemic regions.

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Publication Details

Journal
Clinical Case Reports
Published
2026-01-26
DOI
https://doi.org/10.1002/ccr3.71922
Primary Topic
Hematological disorders and diagnostics
Type
article
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0.00
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article

Miliary Tuberculosis With Immune Thrombocytopenia in 50‐Year‐Old Ethiopian Woman: A Case Report and Brief Review of Literature

Hayatu Awel Abdela, Tamirat Godebo Woyimo, Sisay Tagese Tafese, Ragasa Getachew Bayisa
Clinical Case Reports
Hematological disorders and diagnostics
article

Miliary Tuberculosis With Immune Thrombocytopenia in 50‐Year‐Old Ethiopian Woman: A Case Report and Brief Review of Literature

Hayatu Awel Abdela, Tamirat Godebo Woyimo, Sisay Tagese Tafese, Ragasa Getachew Bayisa
article en

Abstract

Immune thrombocytopenia (ITP) is a rare but recognized hematologic complication of tuberculosis (TB), particularly miliary TB. We present a case of a 50-year-old female with severe thrombocytopenia and hemorrhagic manifestations secondary to miliary TB. The patient presented with mucocutaneous bleeding, anemia, and constitutional symptoms. Investigations revealed severe thrombocytopenia (11,000/μL), erythroid hyperplasia on bone marrow aspiration, and radiographic findings consistent with miliary TB, later confirmed by sputum GeneXpert. Management included short-course high-dose dexamethasone for acute bleeding, followed by anti-tuberculosis therapy (ATT), which led to sustained platelet recovery without further immunosuppression. This case highlights miliary TB as a reversible cause of secondary ITP and underscores the importance of investigating underlying infections in patients presenting with thrombocytopenia in TB-endemic regions.

Clinical Case ReportsVol. 14(2)
Jimma University (ET), Wolkite University (ET)
Gender equality
Openalex Percentile: Top 78%
Hematological disorders and diagnostics
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