Comparison of Epiretinal Membrane Detection Rates Between Optos® and Clarus™ Ultra-Widefield Fundus Imaging Systems

<b>Background:</b> Ultra-widefield (UWF) images are frequently used for fundus examinations during medical screening. Optos^® generates pseudo-color images using only red and green lasers, which may reduce the visibility of retinal interface lesions. In contrast, Clarus™ incorporates blue light, suggesting potential superiority in epiretinal membrane (ERM) detection. <b>Methods:</b> This retrospective study included 233 patients (408 eyes; 816 UWF images per device) who underwent simultaneous Optos^® and Clarus™ imaging plus optical coherence tomography (OCT) at our institution from March to April 2019. Ten blinded ophthalmologists assessed only the UWF images for ERM presence or absence. Diagnosis was confirmed by fundus examination and OCT. McNemar's test compared detection accuracy. <b>Results:</b> Clarus™ consistently outperformed Optos^®, with superior sensitivity [median 49% (range 42-70) vs. 14% (4-47); <i>p</i> = 0.002], correct judgment rate [85% (82-90) vs. 78% (44-88); <i>p</i> = 0.010], and lower unassessed rate [6% (2-13) vs. 13% (3-52); <i>p</i> = 0.002]. This superiority held across ERM stages, lens status, and ophthalmologist experience levels. <b>Conclusions:</b> This study demonstrated that Clarus™ significantly outperformed Optos^® in ERM detection accuracy. These results suggest that true-color UWF systems like Clarus™ may be more useful for macular screening in routine practice and health examinations.