Epigenetic Modifications and Their Role in Type 1 Diabetes Development: A Review
Epigenetic changes form a critical link between genetics, environment, and immune dysfunction in T1DM. By regulating immune responses and β-cell integrity, they drive disease onset and progression. Their study provides opportunities for predictive biomarkers and innovative therapies aimed at reprogramming epigenetic pathways to restore immune tolerance and preserve β-cell function.
Authors
- Iluska Almeida Carneiro Martins de Medeiros
- Thales Allyrio Araújo de Medeiros Fernandes
- José Veríssimo Fernandes
- Tayline Dantas Rodrigues
- Fabiana Lima Bezerra
- Christiane Medeiros Bezerra
- Fernando Liberalino Fernandes
- Jenner Chrystian Veríssimo de Azevedo
- Vania Sousa Andrade
- Joselio Maria Galvão de Araújo
Institutions
- Universidade Federal do Rio Grande do Norte (BR)
- Universidade do Estado do Rio Grande do Norte (BR)
Publication Details
- Journal
- Current Diabetes Reviews
- Published
- 2026-01-20
- DOI
- https://doi.org/10.2174/0115733998399336251122042738
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00