Identifying Susceptibility Genes and Shared Genetic Architecture for Longevity and Muscle Weakness

We identified susceptibility genes for longevity (APOC1, TOMM40) and muscle weakness (DYM, TGFA) and uncovered shared pleiotropic loci linking aging and muscle decline. These findings improve the understanding of the genetic architecture underlying aging-related phenotypes and provide potential molecular targets for promoting healthy aging and reducing late-life disability.

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Publication Details

Journal
Journal of Cachexia Sarcopenia and Muscle
Published
2026-01-26
DOI
https://doi.org/10.1002/jcsm.70197
Primary Topic
Genetics, Aging, and Longevity in Model Organisms
Type
article
Field-Weighted Citation Impact
0.00
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article

Identifying Susceptibility Genes and Shared Genetic Architecture for Longevity and Muscle Weakness

Yue Zhang, Zhiqiang Que, Qingmo Yang, Jing She et al.
Journal of Cachexia Sarcopenia and Muscle
Genetics, Aging, and Longevity in Model Organisms
article

Identifying Susceptibility Genes and Shared Genetic Architecture for Longevity and Muscle Weakness

Yue Zhang, Zhiqiang Que, Qingmo Yang, Jing She, Yilong Lin, Jiawei Chen, Anqi Qiu, Ruiqin Yang, Shengjie Lin, Shinan Wu, Songsong Wang, Ruidan Zhao, Liyi Zhang, Yun Zhang
article en

Abstract

We identified susceptibility genes for longevity (APOC1, TOMM40) and muscle weakness (DYM, TGFA) and uncovered shared pleiotropic loci linking aging and muscle decline. These findings improve the understanding of the genetic architecture underlying aging-related phenotypes and provide potential molecular targets for promoting healthy aging and reducing late-life disability.

Journal of Cachexia Sarcopenia and MuscleVol. 17(1)
Central South University (CN), Guangxi University (CN), Guangxi Medical University (CN), Xiamen University (CN), First Affiliated Hospital of Xiamen University (CN), Xiangya Hospital Central South University (CN), University College London (GB)
Openalex Percentile: Top 76%
Genetics, Aging, and Longevity in Model Organisms
DOIOpen Access PDFOpenAlex
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Identifying Susceptibility Genes and Shared Genetic Architecture for Longevity and Muscle Weakness — Yue Zhang, Zhiqiang Que, et al. · Journal of Cachexia Sarcopenia and Muscle (2026) | TGRS Research Map | TGRS