Design, Synthesis and Blood Vessels Sealing Activity of 2- or 4-methyl-9H-xanthen-9-one Derivatives of Aminophenols or Aromatic Chiral or Achiral Aminoalkanols

The study's findings suggest that 2-methylxanthone derivatives, particularly compound 2, hold potential as vascular sealing agents with additional antiplatelet and vasorelaxant properties. Compound 1, based on the present study, was chosen for further research due to its significant antioxidant properties. These results warrant further pharmacological evaluation for cardiovascular applications.

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Publication Details

Journal
Current Medicinal Chemistry
Published
2026-01-20
DOI
https://doi.org/10.2174/0109298673389529251122103854
Primary Topic
Natural Compound Pharmacology Studies
Type
article
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article

Design, Synthesis and Blood Vessels Sealing Activity of 2- or 4-methyl-9H-xanthen-9-one Derivatives of Aminophenols or Aromatic Chiral or Achiral Aminoalkanols

Katarzyna Brezdeń, Marek Bednarski, Adriana Florko, Dorota Drożdż et al.
Current Medicinal Chemistry
Natural Compound Pharmacology Studies
article

Design, Synthesis and Blood Vessels Sealing Activity of 2- or 4-methyl-9H-xanthen-9-one Derivatives of Aminophenols or Aromatic Chiral or Achiral Aminoalkanols

Katarzyna Brezdeń, Marek Bednarski, Adriana Florko, Dorota Drożdż, Monika Kubacka, Magdalena Kotańska, Anna Maria Waszkielewicz, Karina Madej-Świątkowska
article en

Abstract

The study's findings suggest that 2-methylxanthone derivatives, particularly compound 2, hold potential as vascular sealing agents with additional antiplatelet and vasorelaxant properties. Compound 1, based on the present study, was chosen for further research due to its significant antioxidant properties. These results warrant further pharmacological evaluation for cardiovascular applications.

Current Medicinal ChemistryVol. 33
Jagiellonian University (PL), University School of Physical Education in Kraków (PL), Uniwersytecki Szpital Dziecięcy (PL), Krakow Cardiovascular Research Institute (PL)
Openalex Percentile: Top 76%
Natural Compound Pharmacology Studies
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Design, Synthesis and Blood Vessels Sealing Activity of 2- or 4-methyl-9H-xanthen-9-one Derivatives of Aminophenols or Aromatic Chiral or Achiral Aminoalkanols — Katarzyna Brezdeń, Marek Bednarski, et al. · Current Medicinal Chemistry (2026) | TGRS Research Map | TGRS