Design, Synthesis and Blood Vessels Sealing Activity of 2- or 4-methyl-9H-xanthen-9-one Derivatives of Aminophenols or Aromatic Chiral or Achiral Aminoalkanols
The study's findings suggest that 2-methylxanthone derivatives, particularly compound 2, hold potential as vascular sealing agents with additional antiplatelet and vasorelaxant properties. Compound 1, based on the present study, was chosen for further research due to its significant antioxidant properties. These results warrant further pharmacological evaluation for cardiovascular applications.
Authors
- Katarzyna Brezdeń
- Marek Bednarski
- Adriana Florko
- Dorota Drożdż
- Monika Kubacka
- Magdalena Kotańska
- Anna Maria Waszkielewicz
- Karina Madej-Świątkowska
Institutions
- Jagiellonian University (PL)
- University School of Physical Education in Kraków (PL)
- Uniwersytecki Szpital Dziecięcy (PL)
- Krakow Cardiovascular Research Institute (PL)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2026-01-20
- DOI
- https://doi.org/10.2174/0109298673389529251122103854
- Primary Topic
- Natural Compound Pharmacology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00