Integrated immune profiling of chordomas reveals spatially organized niches and functional heterogeneity
This study advances understanding of the chordoma immune landscape by integrating spatial, transcriptomic, and TCR data. The findings highlight systemic and local immune dynamics, reveal tumor-specific TCR motifs, and identify potential therapeutic targets. These insights provide a foundation for developing personalized immunotherapies to overcome immune suppression and enhance anti-tumor immunity in chordomas.
Authors
- Jean-Paul Wolinsky
- Jason M Miska
- Nicolas Kostelecky
- Junfei Zhao
- Lawrence Jennings
- Yu Han
- Roger Stupp
- Meghan E Cholak
- David Hou
- J Kada Benotmane
- Catalina Lee Chang
- Megan Parker
- Gustavo I Vázquez-Cervantes
- Si Wang
- Victor A Arrieta
- Joshua L Katz
- Maciej S Lesniak
- Hinda Najem
- Erica Vormittag-Nocito
- Brandyn Castro
- Dieter Henrik Heiland
- Rebecca Du
- Pouya Jamshidi
- Chetan Bettegowda
- Amy B Heimberger
- Surya Pandey
- Sze Kiat Tan
- Karl J Habashy
- Lucas Santana-Santos
- James P Chandler
- Adam M Sonabend
- Craig M Horbinski
Institutions
- Northwestern University (US)
- Johns Hopkins University (US)
- University of Freiburg (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Johns Hopkins Medicine (US)
- University Medical Center Freiburg (DE)
- University of Illinois Chicago (US)
- Robert H. Lurie Comprehensive Cancer Center of Northwestern University
- Columbia University (US)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-09-09
- DOI
- https://doi.org/10.1093/neuonc/noaf213
- Primary Topic
- Bone Tumor Diagnosis and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Research Institute
- Northwestern University
- Chordoma Foundation
- Society for Immunotherapy of Cancer
- National Institutes of Health
- National Cancer Institute