Mechanistic insights into fecal microbiota transplantation for the treatment of ulcerative colitis: analysis of the STOP-Colitis trial
Colonic FMT is a more effective delivery route than nasogastric administration. Clinical response is driven by the engraftment of immunomodulatory bacteria that restore a healthy host-microbe dialogue, providing rationale for developing targeted microbial therapeutics.
Authors
- Laura Magill
- Samuel Nicholls
- Andrew D Beggs
- Christopher Quince
- Susan E Manzoor
- Manjinder Kaur
- Caroline Kerbiriou
- Shrushma Loi
- Nicholas J Loman
- Richard Horniblow
- Catherine A Moakes
- Jonathan Segal (ORCID: https://orcid.org/0000-0002-9668-0316)
- Ye H Oo
- Naveen Sharma
- Daniel R Gaya
- Vaios Svolos
- Richard Hansen
- Ailsa L Hart
- Mehmet Yalchin
- Natalie J Ives
- Nicola Crees
- Victoria McCune
- Ben Nichols
- Jonathan Mathers
- Joshua Quick
- Claire McMurray
- Konstantinos Gerasimidis
- Sebastien Raguideau
- Christel McMullan
- Mohammed Nabil Quraishi
- Claire Blackwell
- Peter Hawkey
- Tariq H Iqbal
Institutions
- University of Dundee (GB)
- Glasgow Royal Infirmary (GB)
- South Tees Hospitals NHS Foundation Trust (GB)
- Sheikh Shakhbout Medical City (AE)
- NIHR Birmingham Liver Biomedical Research Unit (GB)
- Earlham Institute (GB)
- St. Mark's Hospital (US)
- Cancer Research UK Clinical Trials Unit (GB)
- Crohn's and Colitis UK (GB)
- St Mark's Hospital (GB)
- NIHR Birmingham Biomedical Research Centre (GB)
- University of Glasgow (GB)
- University of Birmingham (GB)
Publication Details
- Journal
- Journal of Crohn s and Colitis
- Published
- 2026-01-19
- DOI
- https://doi.org/10.1093/ecco-jcc/jjag006
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00