Design, synthesis, and biological evaluation of pyridine-quinazoline-oxadiazole hybrids as novel MELK inhibitors: <i>in-silico</i> analysis, anti-ovarian cancer activity, antioxidant potential, and assessment of cell cycle arrest and apoptosis

The synthesized Pyridine-based hybrids exhibit potent MELK inhibition, promising anticancer activity, and favorable <i>in-silico</i> drug profiles. 14j emerged as strong lead candidate for further anticancer drug development.