A Rare Clown Nose Manifestation of Metastatic Eccrine Porocarcinoma: Case Study and Review of the Literature

The "clown nose" is a rare clinical presentation characterized by reddish-brown nodular lesions localized to the nasal tip. This distinctive sign has been associated with metastatic malignancies, genetic syndromes, and primary dermatologic conditions. We describe a rare case of metastatic eccrine porocarcinoma manifesting as a clown nose in a 54-year-old man with a history of metastatic lung squamous cell carcinoma. In addition, we performed a systematic literature review through PubMed to evaluate infiltration of the nose as a potential indicator of underlying tumor metastasis.

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Publication Details

Journal
American Journal of Dermatopathology
Published
2025-10-29
DOI
https://doi.org/10.1097/dad.0000000000003152
Primary Topic
Cancer and Skin Lesions
Type
article
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article

A Rare Clown Nose Manifestation of Metastatic Eccrine Porocarcinoma: Case Study and Review of the Literature

Sheng Fang, Qin-Xiao Wang, Chao-Ke Zhang, Feng-Zeng Li
American Journal of Dermatopathology
Cancer and Skin Lesions
article

A Rare Clown Nose Manifestation of Metastatic Eccrine Porocarcinoma: Case Study and Review of the Literature

Sheng Fang, Qin-Xiao Wang, Chao-Ke Zhang, Feng-Zeng Li
article en

Abstract

The "clown nose" is a rare clinical presentation characterized by reddish-brown nodular lesions localized to the nasal tip. This distinctive sign has been associated with metastatic malignancies, genetic syndromes, and primary dermatologic conditions. We describe a rare case of metastatic eccrine porocarcinoma manifesting as a clown nose in a 54-year-old man with a history of metastatic lung squamous cell carcinoma. In addition, we performed a systematic literature review through PubMed to evaluate infiltration of the nose as a potential indicator of underlying tumor metastasis.

American Journal of DermatopathologyVol. 48(2)
The Affiliated Yongchuan Hospital of Chongqing Medical University (CN), Chongqing Medical University (CN)
Good health and well-being
Openalex Percentile: Top 21%
Cancer and Skin Lesions
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A Rare Clown Nose Manifestation of Metastatic Eccrine Porocarcinoma: Case Study and Review of the Literature — Sheng Fang, Qin-Xiao Wang, et al. · American Journal of Dermatopathology (2025) | TGRS Research Map | TGRS