Brain-Derived Neurotrophic Factor (BDNF) Regulation by Gut Microbiota for Anti-Aging

Gut microbiota plays a critical role in regulating brain-derived neurotrophic factor (BDNF), thereby contributing to healthy aging and the improvement of neurodegenerative and neuropsychiatric disorders. This review explores the interactions among gut microbiota, BDNF, and aging within the Gut-Brain Axis framework. Evidence from animal and clinical studies indicates that probiotic supplementation and restoration of microbial balance enhance BDNF expression, improve cognitive function, and alleviate symptoms of depression, anxiety, Alzheimer

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Publication Details

Journal
Current Topic in Lactic Acid Bacteria and Probiotics
Published
2025-12-01
DOI
https://doi.org/10.35732/ctlabp.2025.11.2.74
Primary Topic
Gut microbiota and health
Type
article
Field-Weighted Citation Impact
0.00
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article

Brain-Derived Neurotrophic Factor (BDNF) Regulation by Gut Microbiota for Anti-Aging

Jae-Yong Park, Eunyeong Hwang
Current Topic in Lactic Acid Bacteria and Probiotics
Gut microbiota and health
article

Brain-Derived Neurotrophic Factor (BDNF) Regulation by Gut Microbiota for Anti-Aging

Jae-Yong Park, Eunyeong Hwang
article en

Abstract

Gut microbiota plays a critical role in regulating brain-derived neurotrophic factor (BDNF), thereby contributing to healthy aging and the improvement of neurodegenerative and neuropsychiatric disorders. This review explores the interactions among gut microbiota, BDNF, and aging within the Gut-Brain Axis framework. Evidence from animal and clinical studies indicates that probiotic supplementation and restoration of microbial balance enhance BDNF expression, improve cognitive function, and alleviate symptoms of depression, anxiety, Alzheimer

Current Topic in Lactic Acid Bacteria and ProbioticsVol. 11(2)
Good health and well-being
Openalex Percentile: Top 34%
Gut microbiota and health
DOIOpen Access PDFOpenAlex
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Brain-Derived Neurotrophic Factor (BDNF) Regulation by Gut Microbiota for Anti-Aging — Jae-Yong Park, Eunyeong Hwang · Current Topic in Lactic Acid Bacteria and Probiotics (2025) | TGRS Research Map | TGRS