Unveiling the molecular mechanisms of burn injury through integrated single-cell and bulk transcriptomic analysis

This study provides novel insights into the immunological microenvironment of burn injuries. Despite limitations including a modest sample size and lack of experimental validation, our findings establish a foundation for future investigations into targeted immunotherapeutic strategies, potentially improving clinical outcomes and advancing personalized treatment approaches for burn patients.

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Publication Details

Journal
PLoS ONE
Published
2026-01-27
DOI
https://doi.org/10.1371/journal.pone.0341725
Primary Topic
Burn Injury Management and Outcomes
Type
article
Field-Weighted Citation Impact
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article

Unveiling the molecular mechanisms of burn injury through integrated single-cell and bulk transcriptomic analysis

Yanyan Pan, Xiaoyu Zhu, Youfen Fan, Jiliang Li et al.
PLoS ONE
Burn Injury Management and Outcomes
article

Unveiling the molecular mechanisms of burn injury through integrated single-cell and bulk transcriptomic analysis

Yanyan Pan, Xiaoyu Zhu, Youfen Fan, Jiliang Li, Shengyong Cui, Neng Huang, Xin Le
article en

Abstract

This study provides novel insights into the immunological microenvironment of burn injuries. Despite limitations including a modest sample size and lack of experimental validation, our findings establish a foundation for future investigations into targeted immunotherapeutic strategies, potentially improving clinical outcomes and advancing personalized treatment approaches for burn patients.

PLoS ONEVol. 21(1)
Ningbo University (CN), Ningbo No. 2 Hospital (CN)
Openalex Percentile: Top 77%
Burn Injury Management and Outcomes
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