Metastatic and recurrent salivary gland carcinoma: clinical characteristics and comprehensive molecular profiling at a tertiary care center

The impact of immunohistochemical or molecular markers on treatment selection and response was most pronounced in SDC. HER2 IHC2 + expression was observed across multiple subtypes, indicating that TDxd may represent a potential treatment option for more pts than previously anticipated. The impact of comprehensive genomic profiling on targeted treatment options is currently still modest.

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Publication Details

Journal
Journal of Cancer Research and Clinical Oncology
Published
2026-01-27
DOI
https://doi.org/10.1007/s00432-026-06426-8
Primary Topic
Salivary Gland Tumors Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
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article

Metastatic and recurrent salivary gland carcinoma: clinical characteristics and comprehensive molecular profiling at a tertiary care center

Sandra N. Freiberger, Tamara Rordorf, Martina A. Broglie, Tomas Brezina et al.
Journal of Cancer Research and Clinical Oncology
Salivary Gland Tumors Diagnosis and Treatment
article

Metastatic and recurrent salivary gland carcinoma: clinical characteristics and comprehensive molecular profiling at a tertiary care center

Sandra N. Freiberger, Tamara Rordorf, Martina A. Broglie, Tomas Brezina, Martin Zoche, Niels J. Rupp, Joerg Beyer, Gregoire B. Morand, Kristian Ikenberg, Panagiotis Balermpas, Anja Lorch, Simon A. Mueller
article en

Abstract

The impact of immunohistochemical or molecular markers on treatment selection and response was most pronounced in SDC. HER2 IHC2 + expression was observed across multiple subtypes, indicating that TDxd may represent a potential treatment option for more pts than previously anticipated. The impact of comprehensive genomic profiling on targeted treatment options is currently still modest.

Journal of Cancer Research and Clinical OncologyVol. 152(2)
University of Bern (CH), University of Zurich (CH), University Hospital of Bern (CH), University Hospital of Zurich (CH)
Good health and well-being
Openalex Percentile: Top 77%
Salivary Gland Tumors Diagnosis and Treatment
DOIOpen Access PDFOpenAlex
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Metastatic and recurrent salivary gland carcinoma: clinical characteristics and comprehensive molecular profiling at a tertiary care center — Sandra N. Freiberger, Tamara Rordorf, et al. · Journal of Cancer Research and Clinical Oncology (2026) | TGRS Research Map | TGRS