Role of peptidylarginine deiminase 2 in a murine model of traumatic brain injury

Our results suggest that PAD2, but not PAD4, blockade can improve outcomes following TBI, which justifies its exploration as a potential target for novel neuroprotective therapies.

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Publication Details

Journal
The Journal of Trauma: Injury, Infection, and Critical Care
Published
2026-01-27
DOI
https://doi.org/10.1097/ta.0000000000004813
Primary Topic
Rheumatoid Arthritis Research and Therapies
Type
article
Field-Weighted Citation Impact
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article

Role of peptidylarginine deiminase 2 in a murine model of traumatic brain injury

Guang Jin, Kiril Chtraklin, Aleezeh Shaikh, Zaiba Shafik Dawood et al.
The Journal of Trauma: Injury, Infection, and Critical Care
Rheumatoid Arthritis Research and Therapies
article

Role of peptidylarginine deiminase 2 in a murine model of traumatic brain injury

Guang Jin, Kiril Chtraklin, Aleezeh Shaikh, Zaiba Shafik Dawood, Bowen Wang, Wenlu Ouyang, Yongqing Li, Marjorie R. Liggett, Baoling Liu, Hasan B. Alam, Daniel C. Couchenour, Dinesh Jaishankar, Kaijie Zhang, Alvin Anand
article en

Abstract

Our results suggest that PAD2, but not PAD4, blockade can improve outcomes following TBI, which justifies its exploration as a potential target for novel neuroprotective therapies.

The Journal of Trauma: Injury, Infection, and Critical CareVol. 100(2)
Northwestern University (US)
Good health and well-being
Openalex Percentile: Top 78%
Rheumatoid Arthritis Research and Therapies
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