Dietary Use of Hericium coralloides for NAFLD Prevention

<i>Introduction</i>: Today, scientists are searching for alternative approaches to preventing metabolic diseases, particularly non-alcoholic fatty liver disease, which reduces the healthy life expectancy of the working population. Fungi, such as <i>Hericium coralloides</i> (Scop.) Pers., are promising raw materials for extracting bioactive substances with preventative potential. <i>Materials and Methods</i>: This review covered review and research articles published over the last 42 years and indexed in the databases of the eLIBRARY.RU, the National Center for Biotechnology Information, and Scopus. <i>Results and Discussion</i>: It has been established that <i>H. coralloides</i> is valued for its nutritional properties due to its rich protein, fat, and mineral composition. It is in demand for pharmaceutical purposes due to its content of bioactive metabolites. The most studied metabolites are lovastatin and ergothioneine. The activity of these biologically active substances against NAFLD has been confirmed by studies in vitro and in vivo. Market analysis revealed that most dietary supplements contain fungal mycelium or its extract. It is preferable to use pure metabolites of <i>H. coralloides</i> as nutrients in dietary supplements and functional foods, since it allows the scientists to standardize their doses, target the therapeutic effect (immunity, neuroprotection, or antitumor), and reduce the required intake of the product. Since this fungus is a rare species in nature, its biomass should be grown in vitro for industrial use. <i>Conclusions</i>: Further research will focus on developing methods for extracting <i>H. coralloides</i> metabolites and assessing their biopotential in vivo and clinical studies.