Comparative effectiveness of pharmacotherapy for heart failure with preserved ejection fraction: A systematic review and network meta‐analysis
In patients with HFpEF, GLP-1RA, SGLT2i and MRA significantly reduced the risk of cardiovascular death and HF hospitalisation, while GLP-1RA additionally improved the functional and quality-of-life outcomes. GLP-1RA and SGLT2i significantly reduced HF morbidity, and GLP-1RA uniquely improved functional status, positioning adiposity modulation as a central therapeutic target in HFpEF.
Authors
- Hao‐Min Cheng
- Szu‐Han Chen
- Marat Fudim
- Shu‐Mei Yang
- Shao‐Yuan Chuang
- Chi‐Jung Huang
- Yu‐Wen Tseng
- Shih‐Hsien Sung
Institutions
- National Yang Ming Chiao Tung University (TW)
- National Health Research Institutes (TW)
- Taipei Veterans General Hospital (TW)
- Clinical Research Institute (US)
- Duke Medical Center (US)
Publication Details
- Journal
- Diabetes Obesity and Metabolism
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1111/dom.70503
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science and Technology Council