Thrombomodulin facilitates melanoma progression via FAK- and ezrin-mediated phenotypic plasticity

TM promotes melanoma cell plasticity and VM through FAK- and ezrin-dependent pathways. These findings position TM as a key regulator of tumor progression and suggest that targeting TM may offer a novel therapeutic strategy to disrupt cancer cell plasticity and suppress melanoma growth.

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Publication Details

Journal
Journal of Biomedical Science
Published
2026-01-27
DOI
https://doi.org/10.1186/s12929-026-01217-2
Primary Topic
Blood Coagulation and Thrombosis Mechanisms
Type
article
Field-Weighted Citation Impact
0.00

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article

Thrombomodulin facilitates melanoma progression via FAK- and ezrin-mediated phenotypic plasticity

Hua-Lin Wu, Ya-Chu Ku, Ru-Han Sie, Cheng-Lin Wu et al.
Journal of Biomedical Science
Blood Coagulation and Thrombosis Mechanisms
article

Thrombomodulin facilitates melanoma progression via FAK- and ezrin-mediated phenotypic plasticity

Hua-Lin Wu, Ya-Chu Ku, Ru-Han Sie, Cheng-Lin Wu, Chao-Han Lai, Chao-Kai Hsu, Cheng-Hsiang Kuo
article en

Abstract

TM promotes melanoma cell plasticity and VM through FAK- and ezrin-dependent pathways. These findings position TM as a key regulator of tumor progression and suggest that targeting TM may offer a novel therapeutic strategy to disrupt cancer cell plasticity and suppress melanoma growth.

Journal of Biomedical ScienceVol. 33(1)
National Cheng Kung University Hospital (TW), National Cheng Kung University (TW)
National Cheng Kung University, National Science and Technology Council
Good health and well-being
Openalex Percentile: Top 79%
Blood Coagulation and Thrombosis Mechanisms
DOIOpen Access PDFOpenAlex
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