The <i> para <sup>bss1</sup> Drosophila melanogaster </i> as Model for Chronic Nociception: Insights Into Cannabidiol Analgesic Effects
This study proposes the Drosophila melanogaster para<sup>bss1</sup> mutant as a valid and manageable in vivo model for chronic nociception. By exhibiting selective hypersensitivity, resistance to conventional treatment and sensitivity to cannabidiol, this model provides a cost-effective and ethically favourable platform for the preclinical screening of novel analgesics that target sodium channel dysfunctions. This study opens a new avenue for translational pain research and aligns with the ongoing demand for alternative animal models in pain therapeutic development.
Authors
- John George Howland
- Alexandre Souza Marquez
- Lucas Ian Veloso Correia
- Foued Salmen Espíndola
- Serena Mares Malta
- Carlos Ueira‐Vieira
- Lucas Matos Martins Bernardes
- Ana Paula Mendes‐Silva
Institutions
- University of Saskatchewan (CA)
- Universidade Federal de Uberlândia (BR)
Publication Details
- Journal
- European Journal of Pain
- Published
- 2026-01-27
- DOI
- https://doi.org/10.1002/ejp.70225
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- National Institutes of Health