Nightingale: A multimodal approach combining EEG signals and audio features to enhance music therapy

Music therapy has emerged as a promising, yet underutilized, treatment modality in various clinical settings. This paper presents Nightingale, a novel multimodal approach that integrates audio features with electroencephalogram (EEG) signals to predict a subject's emotional response to music. The accuracy of emotional response predictions is enhanced using audio features coupled with EEG data extracted from the Dataset for Emotion Analysis using Physiological and Audiovisual Signals (DEAP). These combined modalities are used to develop a Multilayer Perceptron and Convolutional Neural Network architecture, achieving a Mean Absolute Percentage Error (MAPE) values of 19.52 for valence, 22.16 for arousal, and an R squared of 0.67 for the two domains. This approach offers superior performance to the most recent state-of-the-art in the field. Additionally, it requires significantly less computational resources and a simple network structure, providing an evidence-based prediction technique that could make music therapy more effective and accessible.

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Publication Details

Journal
PLoS ONE
Published
2026-01-27
DOI
https://doi.org/10.1371/journal.pone.0341497
Primary Topic
Emotion and Mood Recognition
Type
article
Field-Weighted Citation Impact
0.00
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article

Nightingale: A multimodal approach combining EEG signals and audio features to enhance music therapy

Nikhil Yadav, Zirui Chen
PLoS ONE
Emotion and Mood Recognition
article

Nightingale: A multimodal approach combining EEG signals and audio features to enhance music therapy

Nikhil Yadav, Zirui Chen
article en

Abstract

Music therapy has emerged as a promising, yet underutilized, treatment modality in various clinical settings. This paper presents Nightingale, a novel multimodal approach that integrates audio features with electroencephalogram (EEG) signals to predict a subject's emotional response to music. The accuracy of emotional response predictions is enhanced using audio features coupled with EEG data extracted from the Dataset for Emotion Analysis using Physiological and Audiovisual Signals (DEAP). These combined modalities are used to develop a Multilayer Perceptron and Convolutional Neural Network architecture, achieving a Mean Absolute Percentage Error (MAPE) values of 19.52 for valence, 22.16 for arousal, and an R squared of 0.67 for the two domains. This approach offers superior performance to the most recent state-of-the-art in the field. Additionally, it requires significantly less computational resources and a simple network structure, providing an evidence-based prediction technique that could make music therapy more effective and accessible.

PLoS ONEVol. 21(1)
University of San Diego (US)
Openalex Percentile: Top 80%
Emotion and Mood Recognition
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Nightingale: A multimodal approach combining EEG signals and audio features to enhance music therapy — Nikhil Yadav, Zirui Chen · PLoS ONE (2026) | TGRS Research Map | TGRS