<scp>Magnetic resonance imaging</scp> ‐negative type <scp>II</scp> focal cortical dysplasia as a subtle form of bottom‐of‐sulcus dysplasia: Electrophysiological and histopathological evidence and treatment implications

MRI-negative type II FCD exhibits sulcus bottom-centered epileptogenicity, consistent with a subtle form of BOSD. These findings support sulcus bottom-targeted MRgLITT as a safe and effective minimally invasive therapy and provide a rationale for sulcus bottom-centered surgical planning in MRI-negative FCD II.

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Publication Details

Journal
Epilepsia
Published
2026-01-27
DOI
https://doi.org/10.1002/epi.70124
Primary Topic
Epilepsy research and treatment
Type
article
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article

Magnetic resonance imaging ‐negative type II focal cortical dysplasia as a subtle form of bottom‐of‐sulcus dysplasia: Electrophysiological and histopathological evidence and treatment implications

Xiangzhi Lu, Kai Zhang, Yuan Yuan, Xuemin Zhao et al.
Epilepsia
Epilepsy research and treatment
article

Magnetic resonance imaging ‐negative type II focal cortical dysplasia as a subtle form of bottom‐of‐sulcus dysplasia: Electrophysiological and histopathological evidence and treatment implications

Xiangzhi Lu, Kai Zhang, Yuan Yuan, Xuemin Zhao, Baotian Zhao, Xiu Wang, Weiyuan Luo, Xiaoqiu Shao, Jianguo Zhang, Chao Zhang, Wenhan Hu, Shan Song, Zhong Zheng, Jiajie Mo
article en

Abstract

MRI-negative type II FCD exhibits sulcus bottom-centered epileptogenicity, consistent with a subtle form of BOSD. These findings support sulcus bottom-targeted MRgLITT as a safe and effective minimally invasive therapy and provide a rationale for sulcus bottom-centered surgical planning in MRI-negative FCD II.

Epilepsia
Capital Medical University (CN), Beijing Tian Tan Hospital (CN), Beijing Institute of Neurosurgery (CN), Beijing Fengtai Hospital (CN)
Openalex Percentile: Top 77%
Epilepsy research and treatment
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