Sepsis induces long-term reprogramming of human HSPCs and drives myeloid dysregulation in sepsis survivors

Together, these findings suggest that sepsis induces lasting reprogramming in HSPCs leading to myeloid progeny with altered immune memory that might drive immune dysregulation in survivors. These data open avenues to explore potential targets to better manage long-term immune alterations in sepsis survivors.

Authors

Institutions

Publication Details

Journal
Journal of Inflammation
Published
2026-01-27
DOI
https://doi.org/10.1186/s12950-025-00483-5
Primary Topic
Immune responses and vaccinations
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Sepsis induces long-term reprogramming of human HSPCs and drives myeloid dysregulation in sepsis survivors

Vladimír Šrámek, Kamila Bendíčková, Marcela Hortová Kohoutková, Marco De Zuani et al.
Journal of Inflammation
Immune responses and vaccinations
article

Sepsis induces long-term reprogramming of human HSPCs and drives myeloid dysregulation in sepsis survivors

Vladimír Šrámek, Kamila Bendíčková, Marcela Hortová Kohoutková, Marco De Zuani, Natália Vadovičová, Petra Lázničková, Tomáš Tomáš, Ivana Andrejčinová, Stjepan Uldrijan, Alexandra Mýtniková, Veronika Bosáková, Veronika Tomášková, Jiří Hrdý, Kristýna Boráková, Julie Štíchová, Marcela Vlková, Martin Helán, Jan Frič
article en

Abstract

Together, these findings suggest that sepsis induces lasting reprogramming in HSPCs leading to myeloid progeny with altered immune memory that might drive immune dysregulation in survivors. These data open avenues to explore potential targets to better manage long-term immune alterations in sepsis survivors.

Journal of InflammationVol. 23(1)
Charles University (CZ), Masaryk University (CZ), Institute of Haematology and Blood Transfusion (CZ), University Hospital Brno (CZ), St. Anne's University Hospital Brno (CZ), Ústav pro Péči o Matku a Dítě (CZ), General University Hospital in Prague (CZ)
Good health and well-being
Openalex Percentile: Top 76%
Immune responses and vaccinations
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Sepsis induces long-term reprogramming of human HSPCs and drives myeloid dysregulation in sepsis survivors — Vladimír Šrámek, Kamila Bendíčková, et al. · Journal of Inflammation (2026) | TGRS Research Map | TGRS