Alzheimer’s Disease and Related Dementia Among Black Adults Stratified by Nativity

ObjectiveTo explore ADRD prevalence by nativity, comparing U.S.-born and non-U.S.-born Black individuals to uncover risk factor differences and inform targeted interventions.MethodsWe conducted a retrospective cohort study with 77,069 Black individuals from the All of Us Research Program. We analyzed two cohorts, U.S.-born and non-U.S.-born Black individuals with ADRD, using 1:1 propensity score matching to balance key factors. Analyses were performed in R and Python with significance set at α = 0.05.ResultsOf 72,311 U.S.-born and 4,758 non-U.S.-born Black individuals, 1:1 propensity score matching resulted in 4,758 matched participants per group. ADRD prevalence was 3.76% in U.S.-born and 4.12% in non-U.S.-born Blacks, with rates increasing with age and being higher among retirees and the unemployed.ConclusionNon-U.S.-born Black individuals have a higher ADRD risk than U.S.-born Blacks due to SDOH and demographic factors, supporting the need for targeted interventions and further research to address health inequities.