First-trimester adipocytokine levels as predictive biomarkers for preeclampsia: a prospective case-control study

First-trimester adipocytokines demonstrate significant predictive capability for the development of preeclampsia, with resistin showing superior diagnostic performance. The combination of multiple biomarkers enhances predictive accuracy beyond individual markers. These findings support the potential integration of adipocytokine assessment into early pregnancy screening protocols, pending validation in diverse populations.