Casein- and Soy-Based High-Protein Diets Differentially Affect Insulin Resistance and Adipose Tissue Advanced Glycation End Product Accumulation in Obese Diabetic Mice
A casein-HPD was associated with greater insulin resistance in this model, concurrent with increased glycer-AGE accumulation in visceral adipose tissue, whereas the soy-HPD did not result in substantial differences compared with the STD. These observations suggest that the metabolic effects of HPDs may differ depending on the protein source.
Authors
- Hironori Yashima
- Yusaku Mori
- Michishige Terasaki
- Makoto Ohara
- Tomomi Saito
- Daiki Tanno
- Yoshie Shiraga
- Madoka Ogino
- Sho-ichi Yamagishi
- Naoya Osaka
Institutions
- SHOWA Medical University (JP)
Publication Details
- Journal
- Current Developments in Nutrition
- Published
- 2026-01-27
- DOI
- https://doi.org/10.1016/j.cdnut.2026.107647
- Primary Topic
- Advanced Glycation End Products research
- Type
- article
- Field-Weighted Citation Impact
- 0.00