First-line PD-1 blockades combined with TKIs for metastatic non-clear cell renal cell carcinoma: a real-world multicenter retrospective study

PD-1 blockades combined with TKIs appeared an effective and safe choice in first-line treatment of mnccRCC, especially in individuals with good performance status, non-chromophobe/Mit family translocation histologies, and intermediate/poor IMDC classification.

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Publication Details

Journal
Cancer Immunology Immunotherapy
Published
2026-01-27
DOI
https://doi.org/10.1007/s00262-025-04293-9
Primary Topic
Renal cell carcinoma treatment
Type
article
Field-Weighted Citation Impact
0.00

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article

First-line PD-1 blockades combined with TKIs for metastatic non-clear cell renal cell carcinoma: a real-world multicenter retrospective study

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Cancer Immunology Immunotherapy
Renal cell carcinoma treatment
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First-line PD-1 blockades combined with TKIs for metastatic non-clear cell renal cell carcinoma: a real-world multicenter retrospective study

Jiwei Huang, Cheoklong NG, Hui Han, Xuhao Liu, Wensu Wei, Xi Zhong, Taile Jing, Zhiling Zhang, Yulu Peng, Pei Dong, Tingxuan Huang, Minfeng Chen
article en

Abstract

PD-1 blockades combined with TKIs appeared an effective and safe choice in first-line treatment of mnccRCC, especially in individuals with good performance status, non-chromophobe/Mit family translocation histologies, and intermediate/poor IMDC classification.

Cancer Immunology ImmunotherapyVol. 75(2)
Central South University (CN), Sun Yat-sen University (CN), Shanghai Jiao Tong University (CN), Renji Hospital (CN), Sun Yat-sen University Cancer Center (CN), Xiangya Hospital Central South University (CN), First Affiliated Hospital Zhejiang University (CN)
National Natural Science Foundation of China, National Postdoctoral Program for Innovative Talents
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Openalex Percentile: Top 78%
Renal cell carcinoma treatment
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