Elevated Serum <scp>SIRT2</scp> Is Associated With Rapid Progression and Cognitive Impairment in Amyotrophic Lateral Sclerosis
These findings provide preliminary clinical evidence linking elevated serum SIRT2 to disease progression and cognitive impairment in ALS, thereby supporting its role in disease heterogeneity. This work lends clinical support to preclinical insights, suggesting SIRT2 may aid in prognosis prediction and may represent a potential therapeutic target, necessitating further studies.
Authors
- Tianrui Wen
- Shuangwu Liu
- Pengfei Lin
- Jun Zhu
- Ninglu Gao
Institutions
- Shandong University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Muscle & Nerve
- Published
- 2026-01-27
- DOI
- https://doi.org/10.1002/mus.70162
- Primary Topic
- Sirtuins and Resveratrol in Medicine
- Type
- article
- Field-Weighted Citation Impact
- 0.00