Gut–Brain–Jaw Axis: The Emerging Role of Gut Microbiota in Temporomandibular Disorders and Orofacial Pain—A Narrative Review

Current evidence supports a bidirectional gut-brain-jaw communication system influencing both peripheral and central pain mechanisms. Incorporating microbiome-targeted approaches-such as dietary modulation, probiotics, and microbial therapy-may enhance TMD management and promote a more holistic, personalised model of oral rehabilitation.

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Publication Details

Journal
Journal of Oral Rehabilitation
Published
2026-01-27
DOI
https://doi.org/10.1111/joor.70156
Primary Topic
Temporomandibular Joint Disorders
Type
article
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0.00
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article

Gut–Brain–Jaw Axis: The Emerging Role of Gut Microbiota in Temporomandibular Disorders and Orofacial Pain—A Narrative Review

Marco Gargari, Mirko Martelli, Alessio Rosa
Journal of Oral Rehabilitation
Temporomandibular Joint Disorders
article

Gut–Brain–Jaw Axis: The Emerging Role of Gut Microbiota in Temporomandibular Disorders and Orofacial Pain—A Narrative Review

Marco Gargari, Mirko Martelli, Alessio Rosa
article en

Abstract

Current evidence supports a bidirectional gut-brain-jaw communication system influencing both peripheral and central pain mechanisms. Incorporating microbiome-targeted approaches-such as dietary modulation, probiotics, and microbial therapy-may enhance TMD management and promote a more holistic, personalised model of oral rehabilitation.

Journal of Oral RehabilitationVol. 53(4)
University of Rome Tor Vergata (IT)
Openalex Percentile: Top 76%
Temporomandibular Joint Disorders
DOIOpen Access PDFOpenAlex
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Gut–Brain–Jaw Axis: The Emerging Role of Gut Microbiota in Temporomandibular Disorders and Orofacial Pain—A Narrative Review — Marco Gargari, Mirko Martelli, et al. · Journal of Oral Rehabilitation (2026) | TGRS Research Map | TGRS