Hyaluronic acid-coated Poly(L-lactide-co-1,3-trimethylene carbonate) modulate early cellular-scaffold interactions and osteogenic potential: a comprehensive in vitro and in vivo evaluation using mesenchymal stromal cells

HA coating improved scaffold hydrophilicity and promoted early cell adhesion and osteogenic signaling. The findings indicate that HA-coated PLATMC scaffolds support early cellular engagement and osteoconductivity, while long-term outcomes are likely governed by intrinsic scaffold properties. These results highlight the potential of HA-coated PLATMC scaffolds for biofabrication in dentistry, particularly in oral and maxillofacial bone regeneration.