PAX6 Deficiency Compromises the Ability of Limbal Epithelial Stem Cells to Properly Differentiate Into Mature Corneal Epithelial Cells
Our single cell transcriptome of the limbus and cornea of Pax6 het mice indicates that AAK may be due to the increase of dysfunctional stem/eTACs with defects in committing to a corneal epithelial cell fate and differentiation.
Authors
- Ziyou Ren
- Robert M. Lavker
- Xiaolin Qi
- Xiaoping Chen
- Han Peng
- Tsutomu Kume
- Parisa Foroozandeh
- Wending Yang
- Sun Kyong Lee
- Nihal Kaplan
Institutions
- Northwestern University (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2026-01-27
- DOI
- https://doi.org/10.1167/iovs.67.1.56
- Primary Topic
- Corneal Surgery and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00