Limited Sensitivity of Ultrasound‐Guided Fine‐Needle Aspiration Cytology for Occult Nodal Metastases in Early‐Stage Oral Squamous Cell Carcinoma

In patients with early-stage oral cavity squamous cell carcinoma and a clinically negative neck, US-FNAC demonstrates high specificity but limited sensitivity and negative predictive value. These findings indicate that US-FNAC alone is insufficient to exclude occult nodal metastases and should be regarded as an adjunctive diagnostic tool rather than a stand-alone nodal staging strategy.

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Publication Details

Journal
Head & Neck
Published
2026-01-27
DOI
https://doi.org/10.1002/hed.70183
Primary Topic
Head and Neck Cancer Studies
Type
article
Field-Weighted Citation Impact
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article

Limited Sensitivity of Ultrasound‐Guided Fine‐Needle Aspiration Cytology for Occult Nodal Metastases in Early‐Stage Oral Squamous Cell Carcinoma

Gerben E. Breimer, Jan Willem Dankbaar, Roosmarijn S. Tellman, Frank A. Pameijer et al.
Head & Neck
Head and Neck Cancer Studies
article

Limited Sensitivity of Ultrasound‐Guided Fine‐Needle Aspiration Cytology for Occult Nodal Metastases in Early‐Stage Oral Squamous Cell Carcinoma

Gerben E. Breimer, Jan Willem Dankbaar, Roosmarijn S. Tellman, Frank A. Pameijer, Sammy M. Schouten, Dominique N. V. Donders, Bart de Keizer, Remco de Bree
article en

Abstract

In patients with early-stage oral cavity squamous cell carcinoma and a clinically negative neck, US-FNAC demonstrates high specificity but limited sensitivity and negative predictive value. These findings indicate that US-FNAC alone is insufficient to exclude occult nodal metastases and should be regarded as an adjunctive diagnostic tool rather than a stand-alone nodal staging strategy.

Head & Neck
Utrecht University (NL), University Medical Center Utrecht (NL)
Openalex Percentile: Top 76%
Head and Neck Cancer Studies
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