Patient‐Specific Lumped‐Parameter Model for Quantifying Vessel‐Specific Remodeling and Predicting Right Ventricular Function in Pulmonary Hypertension

Our results demonstrate that lumped-parameter models can be calibrated to clinical data to quantify vessel-specific remodeling and simulate RV pressure-volume dynamics to provide useful information for distinguishing among different PH phenotypes. This underscores the potential of computational models as noninvasive, clinically feasible tools for assessing in-depth pulmonary vascular and RV function in PH.

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Publication Details

Journal
Comprehensive physiology
Published
2026-01-26
DOI
https://doi.org/10.1002/cph4.70102
Primary Topic
Pulmonary Hypertension Research and Treatments
Type
article
Field-Weighted Citation Impact
0.00

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article

Patient‐Specific Lumped‐Parameter Model for Quantifying Vessel‐Specific Remodeling and Predicting Right Ventricular Function in Pulmonary Hypertension

Amirreza Kachabi, Naomi C. Chesler, Mitchel J. Colebank, Claudia E. Korcarz et al.
Comprehensive physiology
Pulmonary Hypertension Research and Treatments
article

Patient‐Specific Lumped‐Parameter Model for Quantifying Vessel‐Specific Remodeling and Predicting Right Ventricular Function in Pulmonary Hypertension

Amirreza Kachabi, Naomi C. Chesler, Mitchel J. Colebank, Claudia E. Korcarz, Farhan Raza, Christopher G. Lechuga
article en

Abstract

Our results demonstrate that lumped-parameter models can be calibrated to clinical data to quantify vessel-specific remodeling and simulate RV pressure-volume dynamics to provide useful information for distinguishing among different PH phenotypes. This underscores the potential of computational models as noninvasive, clinically feasible tools for assessing in-depth pulmonary vascular and RV function in PH.

Comprehensive physiologyVol. 16(1)
University of Wisconsin–Madison (US), University of South Carolina (US), Edwards Lifesciences (United States) (US)
American Heart Association, National Institutes of Health, National Center for Research Resources, National Center for Advancing Translational Sciences
Reduced inequalities
Openalex Percentile: Top 78%
Pulmonary Hypertension Research and Treatments
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Patient‐Specific Lumped‐Parameter Model for Quantifying Vessel‐Specific Remodeling and Predicting Right Ventricular Function in Pulmonary Hypertension — Amirreza Kachabi, Naomi C. Chesler, et al. · Comprehensive physiology (2026) | TGRS Research Map | TGRS