Patient‐Specific Lumped‐Parameter Model for Quantifying Vessel‐Specific Remodeling and Predicting Right Ventricular Function in Pulmonary Hypertension
Our results demonstrate that lumped-parameter models can be calibrated to clinical data to quantify vessel-specific remodeling and simulate RV pressure-volume dynamics to provide useful information for distinguishing among different PH phenotypes. This underscores the potential of computational models as noninvasive, clinically feasible tools for assessing in-depth pulmonary vascular and RV function in PH.
Authors
- Amirreza Kachabi
- Naomi C. Chesler
- Mitchel J. Colebank
- Claudia E. Korcarz
- Farhan Raza
- Christopher G. Lechuga
Institutions
- University of Wisconsin–Madison (US)
- University of South Carolina (US)
- Edwards Lifesciences (United States) (US)
Publication Details
- Journal
- Comprehensive physiology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1002/cph4.70102
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- American Heart Association
- National Institutes of Health
- National Center for Research Resources
- National Center for Advancing Translational Sciences