Genetic depletion of the early autophagy protein ATG13 impairs mitochondrial energy metabolism, augments oxidative stress, induces the polarization of macrophages to the M1 inflammatory mode, and compromises myelin integrity in skeletal muscle

Our study shows that impaired ATG13-driven autophagy increases inflammation through sirtuin-1 inactivation and NF-κB activation, suggesting a role for ATG13 in post-exertional malaise (PEM).

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Publication Details

Journal
Inflammation Research
Published
2026-01-27
DOI
https://doi.org/10.1007/s00011-025-02158-6
Citations
1
Primary Topic
Autophagy in Disease and Therapy
Type
article
Field-Weighted Citation Impact
31.52
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article

Genetic depletion of the early autophagy protein ATG13 impairs mitochondrial energy metabolism, augments oxidative stress, induces the polarization of macrophages to the M1 inflammatory mode, and compromises myelin integrity in skeletal muscle

Avik Roy, Animesh Barua, Mubaraq A Toriola, Amy Reyes et al.
1 citations
Inflammation Research
Autophagy in Disease and Therapy
31.52
article

Genetic depletion of the early autophagy protein ATG13 impairs mitochondrial energy metabolism, augments oxidative stress, induces the polarization of macrophages to the M1 inflammatory mode, and compromises myelin integrity in skeletal muscle

Avik Roy, Animesh Barua, Mubaraq A Toriola, Amy Reyes, Leggy A Arnold, Sarojini Bulbule, Emma Timlin, C Gunnar Gottschalk, Omolola Mary Adedeji
article en
1 citations

Abstract

Our study shows that impaired ATG13-driven autophagy increases inflammation through sirtuin-1 inactivation and NF-κB activation, suggesting a role for ATG13 in post-exertional malaise (PEM).

Inflammation ResearchVol. 75(1)
University School of Milwaukee (US), Sierra Nevada College (US), University of Wisconsin–Milwaukee (US), Milwaukee School of Engineering (US)
Openalex Percentile: Top 1%
Autophagy in Disease and Therapy
31.52
DOIOpen Access PDFOpenAlex
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