Annexin A2 Causes Motor Incoordination via Muscle–Cerebellum Axis in Sarcopenia

ANXA2 is a key mediator of the muscle-cerebellum axis in sarcopenia, contributing to muscle atrophy by downregulating Neu2 and motor incoordination by targeting CB2R. Isoliquiritigenin was identified as an effective compound targeting ANXA2 to improve motor deficits. These findings highlight ANXA2 as a potential therapeutic target and suggest isoliquiritigenin as a promising strategy for alleviating motor incoordination associated with sarcopenia.

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Publication Details

Journal
Journal of Cachexia Sarcopenia and Muscle
Published
2026-01-26
DOI
https://doi.org/10.1002/jcsm.70203
Primary Topic
S100 Proteins and Annexins
Type
article
Field-Weighted Citation Impact
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article

Annexin A2 Causes Motor Incoordination via Muscle–Cerebellum Axis in Sarcopenia

Chen Xu, Xinfa Shao, Xinlin Jia, Hanwen Chang et al.
Journal of Cachexia Sarcopenia and Muscle
S100 Proteins and Annexins
article

Annexin A2 Causes Motor Incoordination via Muscle–Cerebellum Axis in Sarcopenia

Chen Xu, Xinfa Shao, Xinlin Jia, Hanwen Chang, Yuxin Zhang, Dongyun Gu, Zengguang Wang, Binbin Wang, Dinghao Luo, Xingzuan Lin, Yixuan Lin, Xianhao Zhou, Tanjun Deng, Yongjin Li, Xin Jiao, Yaokai Gan, Wentao Li
article en

Abstract

ANXA2 is a key mediator of the muscle-cerebellum axis in sarcopenia, contributing to muscle atrophy by downregulating Neu2 and motor incoordination by targeting CB2R. Isoliquiritigenin was identified as an effective compound targeting ANXA2 to improve motor deficits. These findings highlight ANXA2 as a potential therapeutic target and suggest isoliquiritigenin as a promising strategy for alleviating motor incoordination associated with sarcopenia.

Journal of Cachexia Sarcopenia and MuscleVol. 17(1)
Shenzhen University (CN), Shanghai Jiao Tong University (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), Peking University (CN), Shanghai Ninth People's Hospital (CN), Peking University Third Hospital (CN)
Openalex Percentile: Top 77%
S100 Proteins and Annexins
DOIOpen Access PDFOpenAlex
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Annexin A2 Causes Motor Incoordination via Muscle–Cerebellum Axis in Sarcopenia — Chen Xu, Xinfa Shao, et al. · Journal of Cachexia Sarcopenia and Muscle (2026) | TGRS Research Map | TGRS