Assessing transporter‐mediated rifampin–linezolid interaction using physiologically‐based pharmacokinetic modelling
Our study suggested that ABCB1 is the primary transporter responsible for the interaction between rifampin and linezolid. The DDI effect of high-dose rifampin on linezolid plasma exposure is similar to that of standard-dose rifampin.
Authors
- Joel Tarning
- Junjie Ding
- Richard M. Hoglund
- Vinh Hoa Pham
- Hoang Dat Nguyen
Institutions
- Inje University (KR)
- Mahidol University (TH)
- University of Oxford (GB)
- Mahidol Oxford Tropical Medicine Research Unit (TH)
- Infectious Diseases Data Observatory (GB)
Publication Details
- Journal
- British Journal of Clinical Pharmacology
- Published
- 2026-01-26
- DOI
- https://doi.org/10.1002/bcp.70443
- Primary Topic
- Drug Transport and Resistance Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00