Combining OCT and OCT angiography improves differentiation of mild cognitive impairment and Alzheimer’s disease

Integrating OCT- and OCTA-derived metrics significantly improved discriminative performance compared with either modality alone, underscoring their complementary value in capturing distinct structural and vascular alterations associated with cognitive impairment.

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Publication Details

Journal
Alzheimer s Research & Therapy
Published
2026-01-27
DOI
https://doi.org/10.1186/s13195-026-01955-3
Primary Topic
Optical Coherence Tomography Applications
Type
article
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OCT
article

Combining OCT and OCT angiography improves differentiation of mild cognitive impairment and Alzheimer’s disease

Joyce R. Chong, Damon Wong, Suman Singh, Christopher Li-Hsian Chen et al.
Alzheimer s Research & Therapy
Optical Coherence Tomography Applications
article

Combining OCT and OCT angiography improves differentiation of mild cognitive impairment and Alzheimer’s disease

Joyce R. Chong, Damon Wong, Suman Singh, Christopher Li-Hsian Chen, Narayanaswamy Venketasubramanian, Mitchell K. P. Lai, Shiyuan Gong, Jacqueline Chua, An Qi Toh, Leopold Schmetterer, Boon Yeow Tan, Bingyao Tan
article en

Abstract

Integrating OCT- and OCTA-derived metrics significantly improved discriminative performance compared with either modality alone, underscoring their complementary value in capturing distinct structural and vascular alterations associated with cognitive impairment.

Alzheimer s Research & TherapyVol. 18(1)
National University of Singapore (SG), Nanyang Technological University (SG), Singapore National Eye Center (SG), Raffles Institution (SG), Advanced Digital Sciences Center (SG), Singapore Eye Research Institute (SG), Fondation Ophtalmologique Adolphe de Rothschild (FR), Duke-NUS Medical School (SG), St Luke's Hospital (SG), Risun (China) (CN), Medical University of Vienna (AT), Tsinghua University (CN)
Reduced inequalities
Openalex Percentile: Top 77%
Optical Coherence Tomography Applications
DOIOpen Access PDFOpenAlex
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Combining OCT and OCT angiography improves differentiation of mild cognitive impairment and Alzheimer’s disease — Joyce R. Chong, Damon Wong, et al. · Alzheimer s Research & Therapy (2026) | TGRS Research Map | TGRS