Long-term outcomes associated with istradefylline versus catechol-O-methyltransferase inhibitors in patients with Parkinson's disease: a nationwide real-world cohort study

Istradefylline was associated with reduced mortality and treatment escalation but increased fracture risk compared with COMT inhibitors, supporting further evaluation of adenosine A<sub>2A</sub> antagonists.

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Publication Details

Journal
Parkinsonism & Related Disorders
Published
2026-01-27
DOI
https://doi.org/10.1016/j.parkreldis.2026.108211
Primary Topic
Adenosine and Purinergic Signaling
Type
article
Field-Weighted Citation Impact
0.00
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article

Long-term outcomes associated with istradefylline versus catechol-O-methyltransferase inhibitors in patients with Parkinson's disease: a nationwide real-world cohort study

Chengsheng Ju, Li Wei, Anette Schrag, Tsugumichi Sato et al.
Parkinsonism & Related Disorders
Adenosine and Purinergic Signaling
article

Long-term outcomes associated with istradefylline versus catechol-O-methyltransferase inhibitors in patients with Parkinson's disease: a nationwide real-world cohort study

Chengsheng Ju, Li Wei, Anette Schrag, Tsugumichi Sato, Camille Carroll, Thomas Foltynie, Kiyoshi Kubota, Xi Xiong
article en

Abstract

Istradefylline was associated with reduced mortality and treatment escalation but increased fracture risk compared with COMT inhibitors, supporting further evaluation of adenosine A<sub>2A</sub> antagonists.

Parkinsonism & Related DisordersVol. 144
University College London Hospitals NHS Foundation Trust (GB), Tokyo University of Science (JP), Food and Drug Safety Center (JP), NIHR Newcastle Biomedical Research Centre (GB), UCL Biomedical Research Centre (GB), University College London (GB)
Good health and well-being
Openalex Percentile: Top 78%
Adenosine and Purinergic Signaling
DOIOpen Access PDFOpenAlex
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Long-term outcomes associated with istradefylline versus catechol-O-methyltransferase inhibitors in patients with Parkinson's disease: a nationwide real-world cohort study — Chengsheng Ju, Li Wei, et al. · Parkinsonism & Related Disorders (2026) | TGRS Research Map | TGRS