Machine learning identifies disulfidptosis-related gene signature for pancreatic cancer prognosis and immune infiltration

This study establishes a disulfidptosis-based prognostic model for PC, identifying RPN1 and PML as key biomarkers. These findings provide novel insights into PC prognosis and immune dynamics, supporting the development of targeted diagnostic and therapeutic strategies.

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Publication Details

Journal
Discover Oncology
Published
2026-01-27
DOI
https://doi.org/10.1007/s12672-026-04463-w
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
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article

Machine learning identifies disulfidptosis-related gene signature for pancreatic cancer prognosis and immune infiltration

Xiaohan Sun, Yue Pei, Jiajia Li, Meijia Cheng et al.
Discover Oncology
Ferroptosis and cancer prognosis
article

Machine learning identifies disulfidptosis-related gene signature for pancreatic cancer prognosis and immune infiltration

Xiaohan Sun, Yue Pei, Jiajia Li, Meijia Cheng, Jingyan Zhang, Yingchao Qi, Hewen Hu, Yichen Wang, Yutong Zhou, Wenkai Li, Tong Yu, Yunen Liu, Wenjing Ma
article en

Abstract

This study establishes a disulfidptosis-based prognostic model for PC, identifying RPN1 and PML as key biomarkers. These findings provide novel insights into PC prognosis and immune dynamics, supporting the development of targeted diagnostic and therapeutic strategies.

Discover OncologyVol. 17(1)
Shenyang Medical College (CN), Liaoning University of Traditional Chinese Medicine (CN), Yanshan University (CN)
Good health and well-being
Openalex Percentile: Top 78%
Ferroptosis and cancer prognosis
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