Leveraging the Electronic Health Record for Early Detection of Pancreatic Cancer Among 9.4 Million US Veterans

We demonstrate good model discrimination in independent data. Compared with current screening practices targeting only genetically predisposed individuals, its implementation could identify 3 times as many PDAC cases. However, predictors beyond the electronic health record (EHR) may be needed to further improve the feasibility of generalized screening.

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Publication Details

Journal
Clinical and Translational Gastroenterology
Published
2026-01-27
DOI
https://doi.org/10.14309/ctg.0000000000000982
Primary Topic
Pancreatic and Hepatic Oncology Research
Type
article
Field-Weighted Citation Impact
0.00
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article

Leveraging the Electronic Health Record for Early Detection of Pancreatic Cancer Among 9.4 Million US Veterans

Amy Justice, Yu-Xiao Yang, Janet Tate, Melissa Skanderson et al.
Clinical and Translational Gastroenterology
Pancreatic and Hepatic Oncology Research
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Leveraging the Electronic Health Record for Early Detection of Pancreatic Cancer Among 9.4 Million US Veterans

Amy Justice, Yu-Xiao Yang, Janet Tate, Melissa Skanderson, Ronald Hauser, Cynthia Brandt, Louise Wang
article en

Abstract

We demonstrate good model discrimination in independent data. Compared with current screening practices targeting only genetically predisposed individuals, its implementation could identify 3 times as many PDAC cases. However, predictors beyond the electronic health record (EHR) may be needed to further improve the feasibility of generalized screening.

Clinical and Translational Gastroenterology
Yale University (US), VA Connecticut Healthcare System (US), Philadelphia VA Medical Center (US), University of Pennsylvania (US)
Good health and well-being
Openalex Percentile: Top 77%
Pancreatic and Hepatic Oncology Research
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